Folate (Folic Acid)

What is Folate?

Folic Acid is part of the B-Vitamin family and is also known as 'Vitamin B9'. It works alongside and in balance with other B vitamins. Folic Acid is the supplemental form of the nutrient 'Folate', which is found in food. Both Folic Acid and Folate are converted in the body, through several enzyme steps, into the active form, 'methylfolate'.

What does Folate do?

Folate contributes to normal amino acid synthesis, and amino acids are important to a whole range of bodily processes. Folate also has a role in the process of cell division. It is needed for the synthesis of DNA and the replication of new cells, so each time a cell in our body divides, folate is required. This is also why it's so important during pregnancy: folate contributes to maternal tissue growth during pregnancy, when tissue is growing quickly and the demand for folate is much higher.

Folate contributes to normal blood formation. It plays a role in the creation of new red blood cells, which transport oxygen around the body. This is another reason it matters during pregnancy, as the volume of blood circulating in the mother increases. Folate also contributes to normal psychological function, and researchers have reviewed folate in relation to mood. Like other B vitamins, folate contributes to the reduction of tiredness and fatigue, and it contributes to the normal function of the immune system.

Discover 'A nutritionist recommended pregnancy diet guide'.

Why it's in OsteoFriend®

Vitamins B6, Folate and B12 work synergistically to regulate homocysteine metabolism, which is essential for maintaining bone integrity. Elevated homocysteine is associated with impaired collagen cross-linking, reduced bone quality, and increased fracture risk. Vitamin B6 supports collagen formation and neurotransmitter synthesis, while Folate and Vitamin B12 are essential for DNA synthesis, methylation and bone marrow function. Deficiencies in any of these B vitamins can disrupt osteoblast activity, compromise bone matrix quality and increase the risk of osteoporosis.¹

Why it's in Daily Multivitamin

Folate is converted to its active form, tetrahydrofolate (THF), which is involved in one-carbon transfer reactions necessary for DNA synthesis, repair, and methylation. A large percentage of women are inefficient at converting folic acid into its active form, methylfolate, and this inability to convert effectively has been indicated in a large number of health conditions and pregnancy complications. In its active form, folate is needed for synthesising purines and thymidylate, the building blocks of DNA. Adequate folate intake is crucial for preventing neural tube defects (NTDs) during foetal development. Folate also supports red blood cell production and DNA synthesis in both the mother and developing foetus. Folate supports DNA synthesis and repair, vital for cell division, particularly in tissues with high turnover rates, such as skin, hair and the immune system.

Why it's in UltraEnergy

Folate is essential for DNA synthesis, methylation and red blood cell production. It indirectly supports energy by ensuring efficient cell division and oxygen transport throughout the body. Folate is a key cofactor in one-carbon metabolism, required for the synthesis of purines and thymidylate, which are essential for DNA replication and cell division. It also plays a central role in methylation reactions via its involvement in the conversion of homocysteine to methionine, supporting gene regulation and neurotransmitter synthesis. Folate is critical for erythropoiesis, as it enables the proper maturation of red blood cells, which are responsible for oxygen delivery to tissues. By facilitating efficient cellular replication and maintaining oxygen transport capacity, folate indirectly supports optimal energy levels and reduces fatigue associated with megaloblastic anaemia.²

Why it's in Pregnancy Multinutrient

The role of Folate deficiency in neural tube defects has been long established.³ Aside from the prevention of neuro tube defects, Folate supplementation helps prevent megaloblastic anaemia, which remains a significant problem for pregnant women. Foetal folate status is prioritised, and therefore folate supplementation is as much for the health of the mother as it is for the baby.⁴ Low folate status during pregnancy may lead to low birth weight and a higher risk of developing long-term adverse effects.⁴

Why it's in Kid's ProMulti

Folate (B9): Supports nucleotide synthesis and methylation reactions; methylated folate bypasses MTHFR polymorphism-related limitations.

Why it's in Men's ProMulti

Folate is essential for DNA synthesis, red blood cell formation, and the regulation of homocysteine levels, all of which are important for cardiovascular health. Folate, along with Vitamins B6 and B12, helps reduce homocysteine levels, which is a risk factor for heart disease. Adequate Folate intake is particularly crucial for men who are considering fatherhood, as it has been shown to improve sperm health and motility. Folate also supports cognitive function and may reduce the risk of neurological disorders associated with ageing.⁵

Why it's in PMS Hero®

Folate, Vitamin B3 (niacin), Vitamin B5 (pantothenic acid), and Vitamin B6 play significant roles in managing premenstrual syndrome (PMS) symptoms through their contributions to hormonal balance and neurotransmitter synthesis. These B Vitamins support mood regulation, reduce fatigue and improve common symptoms such as irritability, bloating and cramping.

Folate acts as a coenzyme in the conversion of homocysteine to methionine via the MTHFR (methylenetetrahydrofolate reductase) pathway. This promotes a reduction in homocysteine and its associated inflammation. Folate plays a vital role in the synthesis of neurotransmitters, including serotonin and dopamine, which can influence mood and emotional wellbeing. Low levels of folate are linked to an increased risk of depression and anxiety, making it essential during PMS.

Why it's in Women's ProMulti

Folate is converted to its active form, tetrahydrofolate (THF), which is involved in one-carbon transfer reactions necessary for DNA synthesis, repair and methylation. A large percentage of women are inefficient at converting folic acid into its active form, methylfolate. This inability to convert effectively has been indicated in a large number of health conditions and pregnancy complications. In its active form, folate is needed for synthesising purines and thymidylate, the building blocks of DNA. Adequate folate intake is crucial for preventing neural tube defects (NTDs) during foetal development. Folate also supports red blood cell production and DNA synthesis in both the mother and developing foetus. Folate supports DNA synthesis and repair, vital for cell division, particularly in tissues with high turnover rates, such as skin, hair and the immune system. Women’s ProMulti contains methylfolate.

Why it's in HeartPro®

Folate is needed for homocysteine metabolism because it is a cofactor in the conversion of homocysteine to methionine. Raised homocysteine levels are an independent risk factor for cardiovascular disease, contributing to endothelial dysfunction, oxidative stress, and vascular inflammation.

Why it's in Hair Saviour®

Folate deficiency is widespread, with up to 50% of the population being deficient in folate.^6,7 Folate deficiency can cause hair changes.

DNA synthesis: Folate is needed for normal DNA synthesis and cell division. It is required in larger quantities by fast-dividing cells such as hair cells.

Blood flow: It supports healthy hair growth by promoting the rapid cell division needed for follicular regeneration. Folate also helps in producing red blood cells, which ensures an adequate oxygen supply to the scalp.