Metabolaid®

What is Metabolaid®?

Metabolaid® is a branded blend of two plant extracts: hibiscus (Hibiscus sabdariffa) and lemon verbena (Aloysia citrodora). Both plants have long been enjoyed as herbal teas, and both are rich in polyphenols, the natural plant compounds behind many of their colours and flavours.

What does the research say about Metabolaid®?

The blend has been clinically studied by its makers, who have looked at its effects on metabolism, appetite and body weight.

Why it's in Weight Management Support

Metabolaid® activates AMPK pathways in adipose tissue, muscles and liver, which enhances mitochondrial activity, increases energy consumption and promotes the use of stored energy.

Appetite regulation: Increases anorexigenic hormones (e.g. GLP-1), decreases orexigenic hormones (e.g. ghrelin). This can lead to reduced calorie intake.¹ GLP-1 is a key hormone for managing blood sugar and enhancing fullness, which helps control appetite and support weight management. Metabolaid® delivers fast action, boosting GLP-1 secretion by 13% compared to placebo just 15 minutes after intake, helping you feel fuller, faster. Over time, this increase in GLP-1 continues to rise, reaching more than 60% after two months, providing sustained support for effective weight management.

Activation of AMPK (AMP-activated protein kinase): Enhances energy expenditure and fat oxidation and improves glucose metabolism. Metabolaid® in animal studies led to increased AMPK phosphorylation, decreased adipogenesis and increased thermogenesis (e.g. increased UCP1/2 mRNA in adipose).²

Anti-inflammatory effects: Reduction in inflammatory cytokines (TNF-α, IL-6) in animal models. This may help counteract the low-grade inflammation seen with visceral fat accumulation in menopause.³

Body fat (especially abdominal) reduction: In clinical human trials, observed reductions in body fat and waist circumference, independent of diet / exercise in some studies.⁴ A trial of 300 mg/day Metabolaid® (lemon verbena and hibiscus polyphenols) for three months in overweight adults (not specifically menopausal) resulted in a -3.4% reduction in body weight, with most weight loss from fat mass and notable abdominal fat reduction. No significant muscle or water loss.⁴ In another RCT, Hibiscus and Lemon verbena polyphenols were shown to modulate appetite-related biomarkers in overweight subjects. Weight, skinfolds and arm and abdominal circumferences improved; there were increases in GLP-1, decreases in ghrelin; better subjective satiety.¹

Improves metabolic health: Metabolaid® increases Bifidobacterium and Faecalibacterium, supporting better insulin sensitivity and promoting a healthy microbiome balance. Metabolaid® maintains Akkermansia and Lactobacillus, contributing to reduced body fat and effective weight management. Metabolaid® increases Prevotella, promoting a healthier and more balanced gut environment. Metabolaid® balances key bacteria like Blautia and Faecalibacterium, fostering efficient metabolism and positive gut health. In a randomised, double-blind, placebo-controlled trial, participants taking a dietary supplement containing 500 mg of Metabolaid® daily, as part of an equilibrated isocaloric diet, showed notable changes over 2 months: LDL levels decreased by 19.6%. HDL levels were maintained, suggesting that keeping these levels stable is beneficial for cardiovascular health.

Changes in Cholesterol Levels in Overweight Individuals: A Comparative Study of Placebo vs Metabolaid®

Intra-group statiscal analysis at the endpoint compared to the baseline is reported as follows: **p <0.01; ***p <0.001; ****p <0.0001

Prevotella: Enhancement of Satiety and Metabolic Regulation

Akkermansia: Regulation of Metabolism and Insulin Sensitivity

Bifidobacterium: Regulation of Metabolism and Insulin Sensitivity

Lactobacillus: Maintaining Intestinal Health and Metabolic Balance

Faecalibacterium: Regulation of Metabolism and Insulin Sensitivity

Blautia: Regulation of Short-Chain Fatty Acid Production and Energy Metabolism