Supplements and Testing for Anxiety and Depression

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Supplement considerations

Stay Calm®

L-theanine promotes relaxation without drowsiness, reduces stress responses and supports cognitive function. Schisandra ensures that tryptophan is converted into serotonin rather than neurotoxic quinolinic acid. Rhodiola regulates the levels of serotonin and dopamine, supporting good moods.

Vegan Omega 3

Omega 3s, particularly EPA and DHA, reduce inflammation in the brain, improve neurotransmitter function and support mood regulation. Studies show they are effective in reducing symptoms of depression.1

Ashwagandha KSM-66®

An adaptogen that helps reduce cortisol (stress hormone) levels, improving resilience to stress and reducing symptoms of anxiety and depression.

Magnesium Glycinate

Magnesium plays an essential role in nervous system function, supporting relaxation and reducing stress. It helps regulate neurotransmitters and has been shown to reduce symptoms of anxiety and depression.2

Brain Fuel®

B vitamins, particularly B6, B9 (folate) and B12, are essential for neurotransmitter synthesis, including serotonin and dopamine. Deficiency is associated with increased risk of mood disorders. Phosphatidylserine, Ginkgo Biloba and Bacopa are neuroprotective and improve blood flow to the brain.

Gut Works®

A healthy gut is essential for the conversion of L-tryptophan into serotonin. A healthy gut microbiome has an anti-inflammatory effect on the entire body. Improving systemic inflammation has been shown to improve mood.

Vitamin D3 & K2

Vitamin D deficiency is linked to increased risk of depression and anxiety. It supports serotonin production and neurotransmitters involved in mood regulation.3

Client handout – talk to your practitioner regarding the best supplementation for you. You may want to ask them about:

  • Ashwagandha
  • Magnesium
  • Vitamin D
  • Omega 3
  • B vitamins
  • L-theanine
  • Probiotics
  • Choline
  • DRV+ Stay Calm®

Testing considerations

Test Marker Rationale
Vitamin D levels 25-Hydroxyvitamin D Low vitamin D is linked to increased risk of depression and mood disorders.
Thyroid function tests TSH, Free T3, Free T4, reverse T3 Thyroid dysfunction, particularly hypothyroidism, can contribute to symptoms of depression and anxiety.
Inflammatory markers CRP, IL-6 Chronic inflammation has been linked to mood disorders and high CRP levels may indicate underlying inflammation.
Blood sugar & insulin levels Fasting Glucose, Fasting
Insulin, HbA1c
Blood sugar imbalances can contribute to mood swings, anxiety and fatigue.
Hormonal panel Cortisol, DHEA, Oestrogen, Progesterone, Testosterone Hormonal imbalances can contribute to anxiety and depression, particularly in women with oestrogen/progesterone imbalances or men with low testosterone.
References
1. Integr Med Res. 2015 Jul 15;4(3):132–141.
2. Cureus. 2024 Oct 13;16(10):e71392.
3. Curr Nutr Rep. 2022 Sep 13;11(4):675–681.